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In this new publication led by scientists at Novartis and the University of Tübingen, the authors take a deep, engineering level look at the performance of a microphysiological liver on chip model for predicting human hepatic clearance, a central parameter in preclinical drug development.
Learn about an innovative three-organ microphysiological system (MPS) designed to improve drug safety during pregnancy.
One crucial factor that plays a pivotal role in the success of organ-on-cip models is immunocompetence. In this blog post, we delve into the significance of immunocompetence in organ-on-chip models and how it opens new avenues for advancing medical research.
In this blog we will provide you with an introduction to the drug development process from target validation to post-market surveillance to give you a better understanding on how new drugs are being developed.
Summary of our work that established a human liver microphysiological model as an in vitro platform for the evaluation of drug-induced liver injury, published in Nature Scientific Reports. This case study sheds light on the effects of the known hepatotoxic antibiotic trovafloxacin and the commonly used analog levofloxacin on human liver tissue, using an innovative chip-based liver model.