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Organ-on-chip applications by organ type – what has been done?

Organ-on-chip applications by organ type – what has been done?

In a previous blog, we talk about applications of organ-on-chip technology for biomedical research and drug development. Here we would like to provide you with examples for specific organ models that have been used in the past, providing the respective literature for your reference. If you start looking yourself, you will be able to identify original research on more applications than the ones listed here. There are too many to mention them all, but we do hope this will provide you with a good overview to start with.

Organ

Application

Reference

Heart

Cardiac ischemia on-a-chip to investigate myocardial tissue under hypoxia

Physiology studies such as to study beating cycle and the influence of electrical stimulation on the contraction force

Heart-on-a-chip to simulate cardiac fibrosis

Heart-on-chip for drug screening

Vasculature

Study clot formation to analyse thrombosis and angiogenesis

Culture of endothelial cell layers with improved perfusion conditions on biochip

Prediction of immune-related antibody-induced toxicity

Large-scale drug screening applications

Placenta

Transfer of substances via the blood-placenta barrier

Kidney

Blomerulus-on-a-chip and diabetic kidney model to study diabetic nephropathy

Modeling opioid disposition in a kidney-on-chip

Modeling of proximal tubular solute secretion

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Pharmacokinetic of gentamicin in a perfused kidney-on-a-chip

Lung

Alveolus-on-chip model to study viral-bacterial co-infection

Alveolus-on-chip model to study viral infection with SARS-CoV-2.

Alveolus-on-chip model to study fungal infection with Aspergillus fumigatus

Alveolus-on-chip model to study the effect of antiviral treatment on SARS-CoV-2 infection

Airway-on-a-chip for analysis of lung inflammation and drug responses

Intestine

Immunocompetent intestine-on-chip model for functional and microbial interaction studies

Modeling of intravenous caspofungin administration using an intestine-on-chip

Influence of microbiome and mechanical deformation on intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Study factors for villus differentiation in intestinal-on-chip model

Liver

Platform for Simulating Drug Metabolism Along the Gut-Liver Axis + microbiome

Studying the protective effect of Vitamine E on inflammation in a liver-on-chip

Toxicologal testing of taurolidine

In vitro organoid model of the human liver sinusoid to study inflammation-associated hepatocellular dysfunction

Establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophages and a hepatic layer comprising stellate cells co-cultured with hepatocytes

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin

Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model

Bacterial infection with Staphylococcus aureus in a liver-on-chip model

Brain

Epileptic seizure model of the brain to mimic local and circuitry function.

Blood-brain-barrier model to study neuroinflammation upon disruption of the endothelial layer in response to inflammatory signals

Gene delivery mechanisms though the blood-brain barrier

Cancer/ Tumor

Investigation of anti-tumoral microenvironment with a perfused three-dimensional human tumor model

Cancer-on-a-chip platforms to study metastatic microenvironment

Human Organ-Specific 3D Cancer Models to study Solid Tumors

Cancer-on-a-chip for modeling immune checkpoint inhibitor and tumor interactions

Tumor-on-a-chip to study cell response to environmental gradients

If you have published using organ models or have a publication that you think should be included in this list feel free to get in touch and we are more than happy to add it to the list.

More interesting articles:

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This blog lists examples of organ-on-chip models by organ type that have been used in the past, providing the respective literature for your reference.

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One crucial factor that plays a pivotal role in the success of organ-on-cip models is immunocompetence. In this blog post, we delve into the significance of immunocompetence in organ-on-chip models and how it opens new avenues for advancing medical research.

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