Organ-on-chip applications by organ type – what has been done?

Organ

Application

Reference

Heart

Cardiac ischemia on-a-chip to investigate myocardial tissue under hypoxia

Veldhuizen et al. (2023)

Ren et al. (2013)

Physiology studies such as to study beating cycle and the influence of electrical stimulation on the contraction force

Kaneko et al. (2007)

Aung et al. (2017)

Heart-on-a-chip to simulate cardiac fibrosis

Lind et al. (2017)

Heart-on-chip for drug screening

Agarwal et al. (2014)

Ren et al. (2021)

Vasculature

Study clot formation to analyse thrombosis and angiogenesis

Zhang et al. (2017)

Culture of endothelial cell layers with improved perfusion conditions on biochip

Raasch et al. (2015)

Prediction of immune-related antibody-induced toxicity

Reference

Large-scale drug screening applications

Phan et al. (2020)

Placenta

Transfer of substances via the blood-placenta barrier

Gresing et al. (2021)

Kidney

Blomerulus-on-a-chip and diabetic kidney model to study diabetic nephropathy

Wang et al. (2017)

Modeling opioid disposition in a kidney-on-chip

Imaoka et al. (2021)

Modeling of proximal tubular solute secretion

Chapron et al. (2020)

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Jang et al. (2013)

Pharmacokinetic of gentamicin in a perfused kidney-on-a-chip

Kim et al. (2016)

Lung

Alveolus-on-chip model to study viral-bacterial co-infection

Deinhardt-Emmer et al. (2020)

Schicke et al. (2020)

Alveolus-on-chip model to study viral infection with SARS-CoV-2.

Deinhardt-Emmer et al. (2021)

Alveolus-on-chip model to study fungal infection with Aspergillus fumigatus

Hoang et al. (2022)

Alveolus-on-chip model to study the effect of antiviral treatment on SARS-CoV-2 infection

Jungwirth et al. (2022)

Airway-on-a-chip for analysis of lung inflammation and drug responses

Benam et al. (2016)

Intestine

Immunocompetent intestine-on-chip model for functional and microbial interaction studies

Maurer et al. (2019)

Modeling of intravenous caspofungin administration using an intestine-on-chip

Kaden et al. (2024)

Influence of microbiome and mechanical deformation on intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Kim et al. (2015)

Study factors for villus differentiation in intestinal-on-chip model

Kim et al. (2013)

Liver

Platform for Simulating Drug Metabolism Along the Gut-Liver Axis + microbiome

Lucchetti et al. (2024)

Lucchetti et al. (2021)

Studying the protective effect of Vitamine E on inflammation in a liver-on-chip

Pein et al. (2018)

Toxicologal testing of taurolidine

Fahrner et al. (2017)

In vitro organoid model of the human liver sinusoid to study inflammation-associated hepatocellular dysfunction

Gröger et al. (2016)

Establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophages and a hepatic layer comprising stellate cells co-cultured with hepatocytes

Rennert et al. (2015)

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin

Kaden et al. (2023)

Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model

Fahrner et al. (2023)

Bacterial infection with Staphylococcus aureus in a liver-on-chip model

Siwczak et al (2022)

Brain

Epileptic seizure model of the brain to mimic local and circuitry function.

Pelkonen et al. (2020)

Blood-brain-barrier model to study neuroinflammation upon disruption of the endothelial layer in response to inflammatory signals

Raasch at al. (2016)

Gene delivery mechanisms though the blood-brain barrier

Englert et al. (2016)

Cancer/ Tumor

Investigation of anti-tumoral microenvironment with a perfused three-dimensional human tumor model

Pergola et al. (2017)

Cancer-on-a-chip platforms to study metastatic microenvironment

Portillo-Lara et al. (2016)

Human Organ-Specific 3D Cancer Models to study Solid Tumors

Roy et al. (2020)

Cancer-on-a-chip for modeling immune checkpoint inhibitor and tumor interactions

Jiang et al. (2021)

Tumor-on-a-chip to study cell response to environmental gradients

Ayuso et al. (2019)