Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak FNS, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS. A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials. 2019 Nov;220:119396. https://doi.org/10.1016/j.biomaterials.2019.119396
Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS. Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development. Advanced Drug Delivery Reviews. 2019 Feb;140:51–67. https://doi.org/10.1016/j.addr.2018.06.008
2018
Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh C, Guilet D, et al. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications. 2018 Sep;9(1) https://doi.org/10.1038/s41467-018-06158-5
2017
Mosig AS. Organ-on-chip models: new opportunities for biomedical research. Future Science OA. 2017 May;3(2):FSO130. https://doi.org/10.4155/fsoa-2016-0038
Gröger M, Lange M, Rennert K, Kaschowitz T, Plettenberg H, Hoffmann M, Mosig AS. Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Engineering in Life Sciences. 2017 Jan;17(5):585–593. https://doi.org/10.1002/elsc.201600162
Mosig A, Nawroth J, Loskill P. Organs-on-a-Chip: Neue Perspektiven in der Medikamentenentwicklung und Personalisierten Medizin. Deutsche Zeitschrift für Klinische Forschung. 2017 02;01
Fahrner R, Möller A, Press AT, Kortgen A, Kiehntopf M, Rauchfuss F, Settmacher U, Mosig AS. Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacology and Toxicology. 2017 Aug;18(1) https://doi.org/10.1186/s40360-017-0168-z
Gröger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS. Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage. Advanced Healthcare Materials. 2017 Sep;7(2):1700616. https://doi.org/10.1002/adhm.201700616
2016
Raasch M, Rennert K, Jahn T, Gärtner C, Schönfelder G, Huber O, Seiler AEM, Mosig AS. An integrative microfluidically supportedin vitromodel of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics. 2016 Jul;10(4):044102. https://doi.org/10.1063/1.4955184
Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, et al. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports. 2016 Feb;6(1) https://doi.org/10.1038/srep21868
2015
Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, et al. Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication. 2015 Mar;7(1):015013. https://doi.org/10.1088/1758-5090/7/1/015013
Rennert K, Steinborn S, Gröger M, Ungerböck B, Jank A, Ehgartner J, Nietzsche S, Dinger J, Kiehntopf M, Funke H, et al. A microfluidically perfused three dimensional human liver model. Biomaterials. 2015 Dec;71:119–131. https://doi.org/10.1016/j.biomaterials.2015.08.043
Disease and Infection Models
2020
Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, et al. Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication. 2020 Feb;12(2):025012. https://doi.org/10.1088/1758-5090/ab7073
Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Glück B, et al. Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages. Microorganisms. 2020 Apr;8(4):577. https://doi.org/10.3390/microorganisms8040577
2016
Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS. A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiology. 2016 Jan;16(1) https://doi.org/10.1186/s12866-015-0621-3
Immune Cells
2017
Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Müller R, Pergola C, Mosig A, et al. Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochemical Pharmacology. 2017 Apr;130:71–82. https://doi.org/10.1016/j.bcp.2017.02.004
Rennert K, Nitschke M, Wallert M, Keune N, Raasch M, Lorkowski S, Mosig AS. Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency. Journal of Tissue Engineering. 2017 Jan;8:204173141772642. https://doi.org/10.1177/2041731417726428
Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig AS, Koeberle A, Werz O. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Scientific Reports. 2017 Jan;7(1) https://doi.org/10.1038/srep41434
2016
Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, et al. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports. 2016 Feb;6(1) https://doi.org/10.1038/srep21868
Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS. Recruitment of CD16 + monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine. 2016 Jul;83:41–52. https://doi.org/10.1016/j.cyto.2016.03.017
2015
Maeß MB, Keller A, Rennert K, Mosig A, Lorkowski S. Optimization of the transfection of human THP-1 macrophages by application of Nunc UpCell technology. Analytical Biochemistry. 2015 Jun;479:40–42. https://doi.org/10.1016/j.ab.2014.12.023
2014
Wallert M, Mosig S, Rennert K, Funke H, Ristow M, Pellegrino RM, Cruciani G, Galli F, Lorkowski S, Birringer M. Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro. Free Radical Biology and Medicine. 2014 Mar;68:43–51. https://doi.org/10.1016/j.freeradbiomed.2013.11.009
2008
Mosig S, Rennert K, Büttner P, Krause S, Lütjohann D, Soufi M, Heller R, Funke H. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Medical Genomics. 2008 Nov;1(1) https://doi.org/10.1186/1755-8794-1-60
Mosig S, Rennert K, Krause S, Kzhyshkowska J, Neunübel K, Heller R, Funke H. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14 + CD16 + monocytes in detoxification of oxidized LDL. The FASEB Journal. 2008 Nov;23(3):866–874. https://doi.org/10.1096/fj.08-118240
New Therapeutic Options/ Nanoparticles
2021
Gresing LJ, Radon P, Friedrich RP, Zahn D, Raasch M, Mosig AS, Dutz S, Alexander C, Wiekhorst F, Hochhaus A, Clement JH. Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials. 2021;521:167535. https://doi.org/.org/10.1016/j.jmmm.2020.167535
2016
Englert C, Trützschler A, Raasch M, Bus T, Borchers P, Mosig AS, Traeger A, Schubert US. Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of Controlled Release. 2016 Nov;241:1–14. https://doi.org/10.1016/j.jconrel.2016.08.039
2015
Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig A, Bauer M, Traeger A, et al. Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo. Journal of Controlled Release. 2015 Oct;216:158–168. https://doi.org/10.1016/j.jconrel.2015.08.008
