The intestine is a very important part of the digestive tract. It serves the absorption of nutrients, the regulation of the water balance, the formation of immune cells as well as the production of hormones and messenger substances.
Our three-dimensional intestinal model, which can be functionally maintained over 15 days, forms Villus-like structures containing the characteristic cell types as well as central tissue-resistant immune cells. This model can be used to investigate questions regarding the uptake of active substances and their transport into the bloodstream as well as direct toxic effects on the intestinal tissue and its barrier function.
By combining these three human organ models, we can also address and analyze a wide range of questions regarding ADMET (absorption, distribution, metabolism, excretion, toxicology) of an active substance.