Organ-on-Chip for ADME & Toxicity Testing
Predict drug safety more reliably and reduce translational failure
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Current toxicology models don’t accurately predict drug safety
The challenge
Only few drugs make it through a long & costly drug development pipeline
What’s happening?
30% of drugs fail in clinical trials due to unforeseen toxicity
The issue
2D cultures and animal models lack predictive value for clinic
The solution
New Approach Methodologies (NAMs) such as AI-based computational modeling, human organ or organoid models, and real-world human data
Organ-on-chip reduces toxicity-related failure rates in clinical trials
More predictive and human-relevant models support reliable decision-making in pre-clinical studies to avoid costly failures. Organ‑on‑Chip technology recreates key aspects of human in vivo physiology in a controlled in vitro setting. This enables earlier identification of human‑relevant toxicities and more accurate dose selection, resulting in higher‑quality drug candidates entering Phase I clinical trials.
Low-adsorption PBT biochips for accurate, reproducible drug safety testing
Reliable toxicology data starts with the right chip material. Our biochips are made from PBT, a biocompatible moldable thermoplastic. All chips are produced via a scalable manufacturing process with low batch-to-batch variation.
Unlike PDMS, PBT exhibits low adsorption even of highly hydrophobic compounds, ensuring stable concentrations of bioactive compounds throughout the assay.
These properties are essential for sensitive, concentration-dependent toxicology applications such as PK/PD and ADME studies, where compound loss can distort toxicity profiles and dose-response curves. By preserving bioactive compound availability, our biochips deliver robust data enabling confident decision-making in pre-clinical drug safety screenings.
Study drug metabolism and de-risk pre-clinical toxicology screenings with multi-organ models
Accurate toxicology relies on understanding not only organ-specific drug effects, but its transport and transformation across the body.
Our organ models can be interconnected to multi-organ models to reproduce in vivo interactions and metabolic pathways. By linking absorption in the lung or intestine, distribution via the vasculature, metabolism in the liver, or excretion, our system enables realistic profiling of drug metabolism and improved prediction of bioavailability. Integrating the liver with secondary organs also allows early assessment of drug‑induced toxicity beyond the primary target organ.
Dynamic drug application for pre-clinical research
In toxicology, ensuring that a drug reaches its target is critical, especially for drugs with low stability. Intravenous drugs are delivered directly into the blood stream, ensuring 100% bioavailability and immediate effects.
Our open platform enables direct intravenous-like dosing via separate injection into the perfusion and integrates a functional vasculature to replicate the endothelial barrier, ensuring realistic drug transport and target exposure.
Real-time monitoring of tissue health and barrier function
Barrier function and oxygen availability is a critical indicator of tissue viability, immune response, and disease processes in organ‑on‑chip models, whether mimicking epithelial barriers like the gut or the vascular endothelium.
Our platform integrates electrodes and sensors for real‑time TEER and oxygen measurements, enabling continuous, non‑invasive monitoring of barrier integrity and tissue oxygenation. This live readout provides immediate insight into drug‑induced effects, tissue dynamics, and disease progression, delivering more predictive toxicology data.
Discover our DynamicOrgan® TEER-Sensor Kit
Discover our DynamicOrgan® O2-Sensor Kit
Downstream analysis for drug metabolism and cell viability
Our platform supports supernatant sampling (e.g. for LC-MS), live cell imaging, and FACS‑based end‑point analysis, enabling detailed characterization of cellular vitality, phenotypic changes, and drug metabolism. These analytical options allow in‑depth investigation of tissue responses and pharmacological behavior, supporting mechanistically informed toxicology and drug development studies.
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Why our solution is unique
- Low adsorption, biocompatible biochips
- Testing of physiologically relevant drug dosages
- Multi-organ systems possible
- Real-time measurement of barrier function (TEER) & oxygen levels
- Easy multiple supernatant sampling or tissue recovery for end-point analysis
- Live cell imaging
- Stable performance (up to 14 days, depending on organ model)
- 3D Architecture formation of organ models
- Immunocompetent – study infiltration of immune cells upon inflammation
Application Areas in Toxicology
- Drug Safety Profiling
- Antibody Safety & Target Profiling
- Tissue Barrier Models
- Uptake/Transport Studies (ADME)
- Cholestasis
- Antibody Recycling
- Infection & Disease Modelling
- Hepatotoxicity
- Lung/ Respiratory Toxicity
Case Studies
Hepatotoxicity – Predict Drug-induced Liver Toxicity Earlier
Drug‑induced liver injury (DILI) remains a major threat to patient safety and a leading cause of drug withdrawals and financial loss for the pharmaceutical industry. Trovafloxacin (TVX) entered clinical trials despite its hepatotoxic effects in humans that conventional preclinical models failed to detect. Using a liver‑on‑chip model, these human‑relevant toxic risks could have been identified earlier, highlighting the potential of Organ‑on‑Chip technology to prevent costly late‑stage failures and improve patient safety.
Read the paper
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Investigate the Mechanisms of Drug-induced Hepatotoxicity
Conventional in vitro models for DILI assessment often focus on hepatocytes alone. Given the complexity of the hepatic microenvironment in vivo, containing liver sinusoidal endothelial cells (LSECs), Kupffer cells, and stellate cells, it is questionable if hepatotoxicity can be reliably predicted.
Using our liver-on-chip model Kaden et al. were able to mimic the complex microenvironment by combining hepatocytes with liver sinusoidal endothelial cells (LSECs) and dissect cell-specific toxicity effects of acetaminophen (APAP). When exposed to the hepatotoxic drug APAP, LSECs and hepatocytes showed higher sensitivity in perfused 3D models compared to 2D co-cultures, cosupporting the importance of physiologically relevant, multi-cellular liver-on-chip models for predictive DILI assessment.
Read the paper
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Predicting Antibody-induced Toxicity
Organ models can be used to predict immune-related antibody-induced toxicities. While immunomodulatory antibodies are key players in the treatment of cancer and inflammatory diseases, they carry a risk of severe immune‑mediated side effects. Vasculature‑on‑chip models enable mechanistic investigation of antibody‑induced toxicities such as cytokine release syndrome or vascular leakage, and support the identification of novel biomarkers for antibody safety assessment.
Learn more about our Vasculature model
Enhancing drug safety during pregnancy
Drug safety assessment during pregnancy remains a major challenge, as pregnant women are often excluded from clinical studies and conventional models fail to reliably predict fetal drug exposure.
To address this gap, Graf et al. developed a three‑organ microphysiological system integrating gut, liver, and placenta models to replicate absorption, metabolism, and placental transfer. Using prednisone as a model compound, the system accurately reflected its metabolization and limited transplacental transfer, with results closely matching clinical data. This study demonstrates how multi‑organ-on‑Chip platforms can provide early-stage into drug safety during pregnancy, supporting more reliable drug safety assessments.
Read the paper
Learn more about our Gut-Liver-Placenta Model
Related Products for Toxicology and ADME
- Build gut-on-chip models to study drug absorption, barrier function, and immune interactions in the intestinal system.
- Includes optimized microfluidic setup for host–microbiome interaction and IBD modeling.
- The kit includes all consumables to model epithelial and endothelial interfaces that mimic the human gut barrier under flow.
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- Create intestinal models with minimal cell input, ideal for rare or patient-derived gut cells.
- Kit contains all consumables to build organ models replicating epithelial and endothelial interfaces between tissue compartments.
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- Measuring the integrity of cellular barriers in a dynamically perfused organ model with TEER
- Kit contains all consumables to measure barrier integrity of organ models replicating epithelial and endothelial interfaces between tissue compartments.
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- Real-time, contact-less, non-invasive detection of oxygen consumption inside an organ model
- Kit contains all consumables to measure oxygen in organ models replicating epithelial and endothelial interfaces between tissue compartments.
More information
In addition to the kit, you will require a peristaltic pump. If you don’t have one you can order a DynamicOrgan® System and will receive a peristaltic pump in addition to your kit of choice.
FAQ for toxicology
Where can I learn how to establish an organ model for my toxicology studies?
In the Dynamic42 Academy, we are providing ...
