The Dynamic42 biochip is a microfluidic platform that facilitates physiologic cell and tissue culture. Its microscopic slide-like design fits in every lab environment and helps you to scale up your cell co-culture. Different channel dimensions offer tremendous options to maximize your readouts, to enrich secreted molecules or to safe precious cell material. Its superior material efficiently limits adsorption of small hydrophobic molecules to the surface. The easy handling of our lab-on-a-chip technology ensures workflows for you. Leverage your cell culture dynamically onto the next level.
The Dynamic42 biochip is provided in a microscopic slide format well adapted to the standard cell culture lab environment. It is made from biocompatible thermoplastics with low adsorption characteristics for small hydrophobic molecules. The microfluidic chip is tightly bonded with biocompatible plastic foils on the top and bottom. It comprises two individually operatable cavities for cell culture applications. The cavities are subdivided by a porous polymer membrane into a top and into a bottom channel. The membrane is tightly sealed into the cavities and customizable in terms of polymer material, pore size and pore density. The Dynamic42 biochip connects via standard luer ports to perfusion tubing and pump equipment. The luer format is widely established in lab and medical devices. There are different channel and cavity dimensions available supporting volumes from 55 µl to 140 µl.
The Dynamic42 Biochip is an easy-to-handle lab-on-chip device built for reliable cell culture research and emulating organs on chips. Its channel design supports air bubble-free microfluidic applications.
Each cavity of the Dynamic42 biochip is subdivided into a top and into a bottom perfusion channel. Each channel is selectable by two luer ports (inlet and outlet). Any pipette tip up to 1250 µl fits into the ports. Cell suspensions, coatings and gels can be introduced individually into each channel enabling the creation of cell layers and complex tissues on both sides of the membrane. The separation of the channels allows to nourish the cells and tissues with individual media and with individual flow rates per channel (or no flow at all). Additionally, circulating cell populations can be introduced. Matching reservoirs facilitate perfusion and ensure nutritional supply up to three days without medium exchange.
This biochip design is characterized by narrow cavities.
This biochip design is characterized by wide cavities with a large cell culture surface comparable to 24 well plates.
This biochip design features cavities with two integrated, superimposed membranes that divide each cavity into three independently operable perfusion channels. A special microcavity variant of the BC003 design enables the immobilization of spheroids and organoids inside the biochip.
This biochip design is characterized by thin, slit-like channel geometries and is well-suited for applications with limited cell material.