DynamicOrgan System

The open organ-on-chip platform

Build human in vitro disease and infection models with the DynamicOrgan System. A system that includes pumps, biochips, consumables and the freedom to keep using standard laboratory equipment. A dynamic system that will help you get greater and more meaningful insights into human biology swiftly and without capital spending.

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What is Organ on Chip Technology?

Simulate human organ function

Organ-on-chip is a technology that reproduces the biology of human organs on a biochip on a small scale. Such organ models reproduce key functions and physiological responses of human organs and tissues, providing human-relevant data for preclinical drug testing and biomedical research.

Physiological flow conditions

Different flow patterns can be achieved through the perfusion of the tissues via microfluidic pumps: pulsatile and laminar – such as in the healthy human body. Watch medium flow through one of our biochips starting from a reservoir, going through the channels into the biochip chambers with an epithelial and endothelial cell layer.

The biochip

Biochips with cell culture chambers, biological or biocompatible artificial membranes and a variety of channel geometries provide the conceptual basis for Organ-on-Chip technology. The channels of such biochips are used to introduce human cells of an organ into the cell culture chamber, to arrange, combine and separate these cells in an in vivo-like fashion and to supply these cells continuously with nutrients. They provide a frame to implement in vivo-like flow patterns similar to the human blood stream.

Membrane – tissue interface and scaffold

The integrated membranes serve as scaffold to arrange human cells, to provide them structural support and a flexible substrate that can mediate mechanical stimulation. Here, complex tissues and tissue-tissue interfaces are created that facilitate intense cell-cell communication, signaling and transport processes.

Integration of immune component

The immune system is a critical component of the human body, playing a vital role in protecting against infections, eliminating diseased cells, and maintaining tissue homeostasis. Via integration of resident and circulating immune cells, organ models can replicate the cellular complexity of the human immune system.

Integration of a microbiome and pathogens

Complex organ models allow for the integration of a microbiome or pathogens to enable the establishment of complex disease and infection models.

Application areas

Tissue Barrier Models/ Transport Studies

Immune Cell Perfusion & Migration

Drug Safety Profiling

Antibody Safety and Target Profiling

Host-Microbiome Interaction

Infection & Disease Modelling

Immunocompetent Organ Models

Liver-on-Chip

Intestine-on-Chip

Lung-on-Chip

Vasculature-on-Chip

Why choose the DynamicOrgan System?

Human relevant data

Multicellular tissue

Vasculature

Immune cells

Microbiome

Pathogens

The open platform

No proprietary equipment or capex spending

Easy handling/integration

Works with established standards

Work with equipment you already have

Scalable sample number and tissue complexity

The DynamicOrgan System workflow

Watch our scientist work with the DynamicOrgan System

This is a short summary video of the most relevant steps conducted in the lab to set up an organ-on-chip model with the DynamicOrgan System. Showcasing steps such as biochip sterilization, cell seeding, perfusion set up and visualization under the microscope.

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Read the application note

How does organ-on-chip compare to other models?

Read what our customers have to say

We are delighted to utilize the Chip for developing our 3D intestine model. This technology has proven to be reliable and consistently reproducible in our experiments. The Chip, combined with the pump and tubing system, provides a comprehensive kit that enables us to culture the 3D model with peristaltic movements, closely mimicking in vivo conditions.
- Dr. Manuela Büttner (Group leader)Medizinische Hochschule Hannover
The Dynamic42 products we have used so far are of excellent quality and durable. The biochips in particular are very standardized and of consistently high quality, which greatly simplifies the reproducibility of experiments. The service is extremely customer-orientated, friendly and helpful. All requests were taken seriously, processed quickly, and answered by the person best qualified for the problem.
- Dr. Susann Hartung (Laboratory Head)Infections in Hematology/Oncology, Leibniz Institute for Natural Product Research and Infection Biology
I have always taken great pleasure in supporting projects together with Dynamic42, as their team exemplifies a harmonious blend of scientific excellence, enthusiasm, and commitment to meet the individual needs of their customers. Their innovative microfluidic platform and chip design offers a distinct combination of features which, coupled with their growing set of pre-established tissue models, strategically positions Dynamic42 well in the current organs-on-chip platform landscape. It is exciting to witness Dynamic42's ongoing portfolio expansion, now enabling customers to conveniently set up the Dynamic42 platform within their respective laboratory environments
- Dr. Marian Raschke (Head of Advanced Cellular Models)Bayer AG
Dynamic42 has a great user-friendly chip design, the know-how and a wonderful team who will train you to feel confident with your first ooc experiment.
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