DynamicOrgan® System
Build human in vitro disease and infection models with the DynamicOrgan® System. An organ-on-a-chip system that will help you get greater and more meaningful insights into human biology swiftly and without capital spending.
The DynamicOrgan® System will include a peristaltic pump and a kit with all required consumables to get started with organ-on-chip technology in your own lab. The kit can be selected depending on the organ model or application that you would like to develop. Take a test to find out which DynamicOrgan® Developers Kit you need.
Why choose the DynamicOrgan® System?
Human relevant data
Multicellular tissue
Vasculature
Immune cells
Microbiome
Pathogens
The open platform
No proprietary equipment or capex spending
Easy handling/integration
Works with established standards
Work with equipment you already have
Scalable sample number and tissue complexity
What is Organ-on-Chip Technology?
Simulate human organ function
Organ-on-chip technology replicates the structure and function of human organs on miniaturized biochips. These advanced in vitro models simulate key physiological responses and tissue interactions, enabling human-relevant data generation for preclinical drug development and biomedical research.
Unlike standard 2D cell culture or animal models, organ-on-chip systems capture the complexity of human biology including perfusion, immune response, and microbiome interactions, offering a new level of predictive power for human applications.
Physiological flow conditions
Different flow patterns can be achieved through the perfusion of the tissues via microfluidic pumps: pulsatile and laminar – such as in the healthy human body. The perfusion provides a crucial mechanical stimulation on the surface of human cells, especially cells from the human blood vessel system (vasculature). These shear forces influence and stimulate receptor decoration on the cell surfaces and have consequently a profound impact on cellular behavior such as growth, signaling/ interaction and metabolism.
The biochip
Biochips with cell culture chambers, biological or biocompatible artificial membranes and a variety of channel geometries provide the conceptual basis for organ-on-chip technology. The channels of such biochips are used to introduce human cells of an organ into the cell culture chamber, to arrange, combine and separate these cells in an in vivo-like fashion and to supply these cells continuously with nutrients. They provide a frame to implement in vivo-like flow patterns similar to the human blood stream inside an in vitro model.
Membrane – tissue interface and scaffold
The integrated membranes serve as scaffold to arrange human cells, to provide them structural support and a flexible substrate that can mediate mechanical stimulation. Here, complex tissues and tissue-tissue interfaces are created that facilitate intense cell-cell communication, signaling and transport processes.
Integration of immune component
The immune system is a critical component of the human body, playing a vital role in protecting against infections, eliminating diseased cells, and maintaining tissue homeostasis. Via integration of resident and circulating immune cells, organ-on-a-chip models can replicate the cellular complexity of the human immune system.
Integration of a microbiome and pathogens
Complex organ models allow for the integration of a microbiome or pathogens to enable the establishment of complex disease and infection models.
Application areas
Tissue Barrier Models/ Transport Studies
Immune Cell Perfusion & Migration
Drug Safety Profiling
Preclinical Drug Development
Antibody Safety and Target Profiling
Host Microbial Interactions
Disease & Infection Modelling
Immunocompetent Organ Models
The DynamicOrgan® System workflow
Watch our scientist Anne-Katrin Bothe demonstrate the DynamicOrgan® System
In this short video, our scientist Anne demonstrates the components that are part of the DynamicOrgan® System. She explains how to assemble the system and gives an introduction into the steps conducted in the lab to set up an organ model. Showcasing steps such as biochip sterilization, cell seeding, perfusion set up and visualization under the microscope.
Speak to us
Read the application note
How does organ-on-chip technology compare to other methods?
What our customers say
Our R&D projects
What is included in the DynamicOrgan® System
The DynamicOrgan® System contains:
Peristaltic Pump
DynamicOrgan® Developers Kit of your choice
Available DynamicOrgan® Developer Kits
Available DynamicOrgan® Sensor Kits
Take the quiz and find the DynamicOrgan® Developers Kit you need!
We’d love to help you find the exact product you need to build your organ model of choice. The tool below will guide you through a series of questions to help you find the right product.
