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References

Publications

Category overview

Drug Development  |  Microphysiological Systems  |  Disease and Infection Models  |  Immune Cells  |  New Therapeutic Options / Nanoparticles

Drug Development

2024

  • Lucchetti, A. K. Oluwasegun, L. Grandmougin, C. Jäger, P. Perez-Escriva, E. Letellier, A. S. Mosig, P. Wilmes, An Organ-on-chip Platform for Simulating Drug Metabolism along the Gut-liver Axis. Adv. Healthcare Mater. 2024, 2303943. 10.1002/adhm.202303943

Microphysiological Systems

2019

  • Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak FNS, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS. A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials. 2019 Nov;220:119396. https://doi.org/10.1016/j.biomaterials.2019.119396
  • Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS. Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development. Advanced Drug Delivery Reviews. 2019 Feb;140:51–67. https://doi.org/10.1016/j.addr.2018.06.008

2018

  • Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh C, Guilet D, et al. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications. 2018 Sep;9(1) https://doi.org/10.1038/s41467-018-06158-5

2017

  • Mosig AS. Organ-on-chip models: new opportunities for biomedical research. Future Science OA. 2017 May;3(2):FSO130. https://doi.org/10.4155/fsoa-2016-0038
  • Gröger M, Lange M, Rennert K, Kaschowitz T, Plettenberg H, Hoffmann M, Mosig AS. Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Engineering in Life Sciences. 2017 Jan;17(5):585–593. https://doi.org/10.1002/elsc.201600162
  • Mosig A, Nawroth J, Loskill P. Organs-on-a-Chip: Neue Perspektiven in der Medikamentenentwicklung und Personalisierten Medizin. Deutsche Zeitschrift für Klinische Forschung. 2017 02;01
  • Fahrner R, Möller A, Press AT, Kortgen A, Kiehntopf M, Rauchfuss F, Settmacher U, Mosig AS. Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacology and Toxicology. 2017 Aug;18(1) https://doi.org/10.1186/s40360-017-0168-z
  • Gröger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS. Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage. Advanced Healthcare Materials. 2017 Sep;7(2):1700616. https://doi.org/10.1002/adhm.201700616

2016

  • Raasch M, Rennert K, Jahn T, Gärtner C, Schönfelder G, Huber O, Seiler AEM, Mosig AS. An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics. 2016 Jul;10(4):044102. https://doi.org/10.1063/1.4955184
  • Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, et al. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports. 2016 Feb;6(1) https://doi.org/10.1038/srep21868

2015

  • Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, et al. Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication. 2015 Mar;7(1):015013. https://doi.org/10.1088/1758-5090/7/1/015013
  • Rennert K, Steinborn S, Gröger M, Ungerböck B, Jank A, Ehgartner J, Nietzsche S, Dinger J, Kiehntopf M, Funke H, et al. A microfluidically perfused three dimensional human liver model. Biomaterials. 2015 Dec;71:119–131. https://doi.org/10.1016/j.biomaterials.2015.08.043

Disease and Infection Models

2024

  • Kaden, T., Alonso-Román, R., Akbarimoghaddam, P., Mosig, A. S., Graf, K., Raasch, M., Hoffmann, B., Figge, M. T., Hube, B., & Gresnigt, M. S. (2024). Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity. Biomaterials, 122525. https://doi.org/10.1016/j.biomaterials.2024.122525

2023

  • Kaden, T., Graf, K., Rennert, K., Li, R., Mosig, A. S., & Raasch, M. Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. Scientific Reports. 2023 Aug;13(1), 13338. https://doi.org/10.1038/s41598-023-40004-z

2022

  • Kaden, T., Noerenberg, A., Boldt, J., Sagawe, C., Johannssen, T., Rennert, K., Raasch, M., & Evenburg, T. Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model. Toxicology. 2022 Nov;483, 153374. https://doi.org/10.1016/j.tox.2022.153374
  • Jungwirth, J., Häring, C., König, S., Giebeler, L., Doshi, H., Brandt, C., Deinhardt-Emmer, S., Löffler, B., & Ehrhardt, C. D,l-lysine-acetylsalicylate + glycine (Lasag) reduces sars-cov-2 replication and shows an additive effect with remdesivir. International Journal of Molecular Sciences. 2022 Jun;23(13), 6880. https://doi.org/10.3390/ijms23136880
  • Hoang, T. N. M., Cseresnyés, Z., Hartung, S., Blickensdorf, M., Saffer, C., Rennert, K., Mosig, A. S., von Lilienfeld-Toal, M., & Figge, M. T. Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection. Biomaterials. 2022 Feb;283, 121420. https://doi.org/10.1016/j.biomaterials.2022.121420

2021

  • Lucchetti, M., Kaminska, M., Oluwasegun, A. K., Mosig, A. S., & Wilmes, P. Emulating the gut–liver axis: Dissecting the microbiome’s effect on drug metabolism using multiorgan-on-chip models. Current Opinion in Endocrine and Metabolic Research. 2021 Mar;18, 94–101. https://doi.org/10.1016/j.coemr.2021.03.003

2020

  • Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, et al. Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication. 2020 Feb;12(2):025012. https://doi.org/10.1088/1758-5090/ab7073
  • Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Glück B, et al. Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages. Microorganisms. 2020 Apr;8(4):577. https://doi.org/10.3390/microorganisms8040577

2016

  • Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS. A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiology. 2016 Jan;16(1) https://doi.org/10.1186/s12866-015-0621-3

Immune Cells

2023

  • Fahrner, R., Gröger, M., Settmacher. U., Mosig, A. S., Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model. BMC Research Notes. 2023 Oct;16, 285. https://doi.org/10.1186/s13104-023-06575-w

2022

  • Siwczak, F., Cseresnyes, Z., Hassan, M. I. A., Aina, K. O., Carlstedt, S., Sigmund, A., Groger, M., Surewaard, B. G. J., Werz, O., Figge, M. T., Tuchscherr, L., Loffler, B., & Mosig, A. S. Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model. Biomaterials. 2022 Jun;287, 121632. https://doi.org/10.1016/j.biomaterials.2022.121632

2017

  • Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Müller R, Pergola C, Mosig A, et al. Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochemical Pharmacology. 2017 Apr;130:71–82. https://doi.org/10.1016/j.bcp.2017.02.004
  • Rennert K, Nitschke M, Wallert M, Keune N, Raasch M, Lorkowski S, Mosig AS. Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency. Journal of Tissue Engineering. 2017 Jan;8:204173141772642. https://doi.org/10.1177/2041731417726428
  • Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig AS, Koeberle A, Werz O. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Scientific Reports. 2017 Jan;7(1) https://doi.org/10.1038/srep41434

2016

  • Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, et al. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports. 2016 Feb;6(1) https://doi.org/10.1038/srep21868
  • Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS. Recruitment of CD16 + monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine. 2016 Jul;83:41–52. https://doi.org/10.1016/j.cyto.2016.03.017

2015

  • Maeß MB, Keller A, Rennert K, Mosig A, Lorkowski S. Optimization of the transfection of human THP-1 macrophages by application of Nunc UpCell technology. Analytical Biochemistry. 2015 Jun;479:40–42. https://doi.org/10.1016/j.ab.2014.12.023

2014

  • Wallert M, Mosig S, Rennert K, Funke H, Ristow M, Pellegrino RM, Cruciani G, Galli F, Lorkowski S, Birringer M. Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro. Free Radical Biology and Medicine. 2014 Mar;68:43–51. https://doi.org/10.1016/j.freeradbiomed.2013.11.009

2008

  • Mosig S, Rennert K, Büttner P, Krause S, Lütjohann D, Soufi M, Heller R, Funke H. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Medical Genomics. 2008 Nov;1(1) https://doi.org/10.1186/1755-8794-1-60
  • Mosig S, Rennert K, Krause S, Kzhyshkowska J, Neunübel K, Heller R, Funke H. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14 + CD16 + monocytes in detoxification of oxidized LDL. The FASEB Journal. 2008 Nov;23(3):866–874. https://doi.org/10.1096/fj.08-118240

New Therapeutic Options/ Nanoparticles

2021

  • Gresing LJ, Radon P, Friedrich RP, Zahn D, Raasch M, Mosig AS, Dutz S, Alexander C, Wiekhorst F, Hochhaus A, Clement JH. Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials. 2021;521:167535. https://doi.org/10.1016/j.jmmm.2020.167535

2016

  • Englert C, Trützschler A, Raasch M, Bus T, Borchers P, Mosig AS, Traeger A, Schubert US. Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of Controlled Release. 2016 Nov;241:1–14. https://doi.org/10.1016/j.jconrel.2016.08.039

2015

  • Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig A, Bauer M, Traeger A, et al. Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo. Journal of Controlled Release. 2015 Oct;216:158–168. https://doi.org/10.1016/j.jconrel.2015.08.008